aiqbench analysis
MAGNET introduces a novel Manifold-Aware Graph Diffusion Network that ensures geometric validity when generating functional brain connectomes from coarse labels. By leveraging normalized-Cholesky representations and relational inductive biases, the model achieves significant improvements in fidelity and sampling efficiency across major neuroimaging cohorts like ABIDE and ADNI. This work advances generative modeling for neuroscience by demonstrating how class-conditional geometry can be recovered to better capture clinical heterogeneity without requiring extensive labeled data.
MAGNET: Manifold-Aware Graph Diffusion Network for Connectome Generation
arXiv:2610.17014v1 Announce Type: cross Abstract: Functional brain connectome represents neural connectivity as a matrix of pairwise interactions between brain regions. Generation of functional connectomes is not only a question of validity; rather, having satisfied the constraints on the correlation matrix, the next step is to recover the class-conditional geometry buried under coarse labels. We propose MAGNET, a Manifold-Aware Graph Diffusion Network which uses a normalized-Cholesky representation of the manifold of correlation matrices that guarantees validity. MAGNET lifts noisy latent states into ROI-level region tokens and performs denoising with a relational inductive bias over brain atlas regions. To deal with structural problems induced by coarse labels, MAGNET employs class-anchored conditioning, amortized structural bridge, and relevance-preserving corruption. Across ABIDE, ADNI, and OASIS-3, MAGNET consistently achieves favorable results compared to previous manifold-aware approaches, demonstrating improvements of 7-21% in class-conditional fidelity ($\alpha,\beta$-F1) across three cohorts and better sampling efficiency. Moreover, while training only with strict binary labels, MAGNET is capable of maintaining clinical heterogeneity through fine substructure of the connectomes in a zero-shot setting, improving subclass covariance alignment ($\lambda$-MSE) by over 30%. These results suggest that geometric validity is a necessary but insufficient condition for clinical utility in connectome synthesis. Moreover, efforts in making the diffusion denoising class-conditional manifold aware finds utility beyond the highly curved brain connectome generation as this is a critical problem in various general settings. The code repository can be found at https://github.com/protyayofficial/MAGNET.
Abstract:Functional brain connectome represents neural connectivity as a matrix of pairwise interactions between brain regions. Generation of functional connectomes is not only a question of validity; rather, having satisfied the constraints on the correlation matrix, the next step is to recover the class-conditional geometry buried under coarse labels. We propose MAGNET, a Manifold-Aware Graph Diffusion Network which uses a normalized-Cholesky representation of the manifold of correlation matrices that guarantees validity. MAGNET lifts noisy latent states into ROI-level region tokens and performs denoising with a relational inductive bias over brain atlas regions. To deal with structural problems induced by coarse labels, MAGNET employs class-anchored conditioning, amortized structural bridge, and relevance-preserving corruption. Across ABIDE, ADNI, and OASIS-3, MAGNET consistently achieves favorable results compared to previous manifold-aware approaches, demonstrating improvements of 7-21% in class-conditional fidelity ($\alpha,\beta$-F1) across three cohorts and better sampling efficiency. Moreover, while training only with strict binary labels, MAGNET is capable of maintaining clinical heterogeneity through fine substructure of the connectomes in a zero-shot setting, improving subclass covariance alignment ($\lambda$-MSE) by over 30%. These results suggest that geometric validity is a necessary but insufficient condition for clinical utility in connectome synthesis. Moreover, efforts in making the diffusion denoising class-conditional manifold aware finds utility beyond the highly curved brain connectome generation as this is a critical problem in various general settings. The code repository can be found at this https URL.
Machine Learning (cs.LG); Artificial Intelligence (cs.AI); Computer Vision and Pattern Recognition (cs.CV)
arXiv:2610.17014 [cs.LG]
(or arXiv:2610.17014v1 [cs.LG] for this version)
https://doi.org/10.48550/arXiv.2610.17014 Focus to learn more arXiv-issued DOI via DataCite (pending registration)
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Full text under the publisher's open licence · 333 words
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