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ESM protein language models for embeddings, sequence scoring, structure prediction, and binder design. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) or mutation-effect scores, (2) Getting protein embeddings for clustering or filtering, (3) Predicting complex structures with ESMFold2, (4) Designing binders by inverting ESMFold2, (5) Filtering designs by sequence plausibility. For diffusion-based structure prediction, use boltz or chai. For QC thresholds, use protein-qc. For gradient-based multi-objective design, use mosaic.

Install

npx skills add adaptyvbio/protein-design-skills --skill esm -a claude-code

Installs to .claude/skills/esm/ · Each command fetches the skill straight from GitHub with the open skills CLI.

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