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This research demonstrates how training neural networks on synthesized data can approximate the optimal Bayes estimator for dense emitter localization, advancing high-throughput super-resolution microscopy techniques. By bridging machine learning with physical imaging constraints, the study provides a rigorous theoretical justification for future large-field-of-view applications in single-molecule localization microscopy (SMLM).
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Training Neural Networks to Approach the Optimum Bayes Estimator in Dense Multi-Emitter Localization

arXiv1 min read

arXiv:2609.20465v1 Announce Type: new Abstract: We train neural networks on synthesized frames to approach the optimum Bayes estimator for dense emitter localization. The result justifies the future work on training neural networks to achieve high-throughput large-FOV super spatiotemporal resolution SMLM.

Abstract:We train neural networks on synthesized frames to approach the optimum Bayes estimator for dense emitter localization. The result justifies the future work on training neural networks to achieve high-throughput large-FOV super spatiotemporal resolution SMLM.

Machine Learning (cs.LG)

arXiv:2609.20465 [cs.LG]

(or arXiv:2609.20465v1 [cs.LG] for this version)

https://doi.org/10.48550/arXiv.2609.20465 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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Full text under the publisher's open licence · 129 words

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