aiqbench analysis
This study applies interpretable deep sequence modeling and EEG microstate analysis to identify distinct neural signatures linking social distress to non-suicidal self-injury in adolescents. By leveraging advanced machine learning techniques, the research successfully isolates disrupted emotion-action coupling dynamics that serve as a potential objective biomarker for this condition. The work represents a significant application of AI/ML methods to decode complex neurodynamic mechanisms in clinical neuroscience.
Social Pain Disrupts Emotion-Action Brain-State Dynamics in Adolescents with Non-Suicidal Self-Injury
arXiv:2610.11155v1 Announce Type: new Abstract: Non-suicidal self-injury (NSSI) is prevalent among adolescents with depression, but the rapid brain-state dynamics linking social distress to maladaptive behavior remain unclear. We combine an experimental pain paradigm, electroencephalography (EEG) microstate analysis, and interpretable deep sequence modeling to investigate NSSI-related neurodynamics in 106 adolescents with depression, including 67 with NSSI (DN+) and 39 without NSSI (DN-), during social pain, physical pain, and resting-state conditions. A model integrating disease-specific, domain-adversarial, consistency, and contrastive learning captures higher-order dependencies in microstate sequences. Social pain yields the strongest NSSI discrimination, with 68.55% accuracy, outperforming the best baseline by 8.94% points. Model interpretation and conventional microstate analyses reveal weakened bidirectional transitions between MS3 and MS5 in DN+ adolescents during social pain. Source reconstruction associates MS3 with emotional/interoceptive processing and MS5 with action preparation, suggesting disrupted emotion-action coupling. Time-resolved analyses show greater early-to-middle action-state recruitment and later emotion-state recruitment in DN+ adolescents. In DN- adolescents, MS5-to-MS3 dynamics mediate associations between social-evaluation sensitivity and affective outcomes, whereas this mediation is absent in DN+; conversely, MS3-to-MS5 transitions are associated with greater negative affect in DN+. Together, these findings identify disrupted emotion-action coupling as a key neurodynamic mechanism underlying altered social pain processing in adolescents with NSSI, providing a mechanistically interpretable neural signature for objective identification of NSSI.
Abstract:Non-suicidal self-injury (NSSI) is prevalent among adolescents with depression, but the rapid brain-state dynamics linking social distress to maladaptive behavior remain unclear. We combine an experimental pain paradigm, electroencephalography (EEG) microstate analysis, and interpretable deep sequence modeling to investigate NSSI-related neurodynamics in 106 adolescents with depression, including 67 with NSSI (DN+) and 39 without NSSI (DN-), during social pain, physical pain, and resting-state conditions. A model integrating disease-specific, domain-adversarial, consistency, and contrastive learning captures higher-order dependencies in microstate sequences. Social pain yields the strongest NSSI discrimination, with 68.55% accuracy, outperforming the best baseline by 8.94% points. Model interpretation and conventional microstate analyses reveal weakened bidirectional transitions between MS3 and MS5 in DN+ adolescents during social pain. Source reconstruction associates MS3 with emotional/interoceptive processing and MS5 with action preparation, suggesting disrupted emotion-action coupling. Time-resolved analyses show greater early-to-middle action-state recruitment and later emotion-state recruitment in DN+ adolescents. In DN- adolescents, MS5-to-MS3 dynamics mediate associations between social-evaluation sensitivity and affective outcomes, whereas this mediation is absent in DN+; conversely, MS3-to-MS5 transitions are associated with greater negative affect in DN+. Together, these findings identify disrupted emotion-action coupling as a key neurodynamic mechanism underlying altered social pain processing in adolescents with NSSI, providing a mechanistically interpretable neural signature for objective identification of NSSI.
Artificial Intelligence (cs.AI)
arXiv:2610.11155 [cs.AI]
(or arXiv:2610.11155v1 [cs.AI] for this version)
https://doi.org/10.48550/arXiv.2610.11155 Focus to learn more arXiv-issued DOI via DataCite (pending registration)
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