aiqbench analysis
Siam-ALS introduces a Siamese deep learning architecture that fuses EEG and eye-tracking data to improve early detection of amyotrophic lateral sclerosis with high accuracy and interpretability. The framework's use of weight-sharing branches and metric learning addresses the challenge of small, heterogeneous medical datasets, offering a robust alternative to classical methods for multimodal physiological signal analysis.
Siam-ALS: An Explainable Siamese Deep Learning Framework for Early ALS Detection Using EEG and Eye-Tracking Signals
arXiv:2610.15351v1 Announce Type: cross Abstract: Amyotrophic lateral sclerosis (ALS) diagnosis remains challenging due to heterogeneous symptoms and reliance on clinical assessment, underscoring the need for objective, data-driven approaches that leverage patient-generated physiological signals. We propose Siam-ALS, an explainable Siamese deep learning framework that jointly models synchronized electroencephalography (EEG) and eye-tracking (ET) signals. EEG captures ALS-related changes in brain activity, while ET provides information about oculomotor control, allowing the model to learn complementary patterns associated with ALS. The framework employs two modality-specific encoders: a convolutional EEG encoder that captures spatiotemporal neural patterns and an MLP-based ET encoder that models oculomotor dynamics. These modality-specific features are processed through weight-sharing Siamese branches and fused into a compact 64-dimensional joint embedding. A lightweight classifier is used to predict ALS, while pairwise metric learning helps the model learn more effective patterns from the small, diverse ALS datasets. Performance was evaluated on the public EEGET-ALS dataset using strict subject-level cross-validation, where Siam-ALS achieved an accuracy of 0.988 and an AUROC of 0.998, demonstrating strong performance compared with classical machine learning, DL, and non-Siamese fusion approaches. Cross-dataset evaluation on the independent BigP3BCI dataset achieved an AUROC of approximately 0.98, supporting the generalization capability of Siam-ALS across different BCI paradigms. To enhance interpretability, six XAI methods were evaluated in the learned embedding space, with SHAP achieving the highest, though statistically comparable, fidelity in identifying important EEG and ET patterns that contribute to ALS predictions. Overall, Siam-ALS provides an accurate, generalizable, and explainable framework for multimodal ALS detection.
Abstract:Amyotrophic lateral sclerosis (ALS) diagnosis remains challenging due to heterogeneous symptoms and reliance on clinical assessment, underscoring the need for objective, data-driven approaches that leverage patient-generated physiological signals. We propose Siam-ALS, an explainable Siamese deep learning framework that jointly models synchronized electroencephalography (EEG) and eye-tracking (ET) signals. EEG captures ALS-related changes in brain activity, while ET provides information about oculomotor control, allowing the model to learn complementary patterns associated with ALS. The framework employs two modality-specific encoders: a convolutional EEG encoder that captures spatiotemporal neural patterns and an MLP-based ET encoder that models oculomotor dynamics. These modality-specific features are processed through weight-sharing Siamese branches and fused into a compact 64-dimensional joint embedding. A lightweight classifier is used to predict ALS, while pairwise metric learning helps the model learn more effective patterns from the small, diverse ALS datasets. Performance was evaluated on the public EEGET-ALS dataset using strict subject-level cross-validation, where Siam-ALS achieved an accuracy of 0.988 and an AUROC of 0.998, demonstrating strong performance compared with classical machine learning, DL, and non-Siamese fusion approaches. Cross-dataset evaluation on the independent BigP3BCI dataset achieved an AUROC of approximately 0.98, supporting the generalization capability of Siam-ALS across different BCI paradigms. To enhance interpretability, six XAI methods were evaluated in the learned embedding space, with SHAP achieving the highest, though statistically comparable, fidelity in identifying important EEG and ET patterns that contribute to ALS predictions. Overall, Siam-ALS provides an accurate, generalizable, and explainable framework for multimodal ALS detection.
Machine Learning (cs.LG); Artificial Intelligence (cs.AI)
arXiv:2610.15351 [cs.LG]
(or arXiv:2610.15351v1 [cs.LG] for this version)
https://doi.org/10.48550/arXiv.2610.15351 Focus to learn more arXiv-issued DOI via DataCite (pending registration)
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