Selection for Selectability: Inductive Biases in Evolution and in Neural Networks

This post was written as part of MATS 9.1 under the mentorship of Richard Ngo, and was written during Iliad Fellowship, to all of whom my thanks. LLM Usage: prose drafted by Claude from my outline, talk materials, and notes. I edited thereafter. There is some residual Claude cringe in the more functional prose, but hopefully most of it is my own and the more entertaining for it. 0.A. Precis Evolution selects not only for having 'good genotype' but for having good genome architecture. Over long timescales, selection reshapes genome architecture so that random mutations produce phenotypes which vary along directions of repeated environmental variation. This genome–environment alignment is mathematically analogous to kernel alignment in neural networks. The comparison rests not on the fatuous observation that both processes can be written as equations resembling gradient descent, but on shared structural motifs - many of the interesting things we've observed about, e.g. loss-landscape geometry, are adumbrated in biology. This post draws the mathematical analogy and introduces the parallels I find most fun - genome–environment alignment ~ feature learning, the mjx-container[jax="CHTML"] { line-height: 0; } mjx-container [space="1"] { margin-left: .111em; } mjx-container [space="2"] { margin-left: .167em; } mjx-container [space="3"] { margin-left: .222em; } mjx-container [space="4"] { margin-left: .278em; } mjx-container [space="5"] { margin-left: .333em; } mjx-container [rspace="1"] { margin-right: .111em; } mjx-container [rspace="2"] { margin-right: .167em; } mjx-container [rspace="3"] { margin-right: .222em; } mjx-container [rspace="4"] { margin-right: .278em; } mjx-container [rspace="5"] { margin-right: .333em; } mjx-container [size="s"] { font-size: 70.7%; } mjx-container [size="ss"] { font-size: 50%; } mjx-container [size="Tn"] { font-size: 60%; } mjx-container [size="sm"] { font-size: 85%; } mjx-container [size="lg"] { font-size: 120%; } mjx-container [size="Lg"] { font-size: 144%; } mjx-container [size="LG"] { font-size: 173%; } mjx-container [size="hg"] { font-size: 207%; } mjx-container [size="HG"] { font-size: 249%; } mjx-container [width="full"] { width: 100%; } mjx-box { display: inline-block; } mjx-block { display: block; } mjx-itable { display: inline-table; } mjx-row { display: table-row; } mjx-row > * { display: table-cell; } mjx-mtext { display: inline-block; text-align: left; } mjx-mstyle { display: inline-block; } mjx-merror { display: inline-block; color: red; background-color: yellow; } mjx-mphantom { visibility: hidden; } _::-webkit-full-page-media, _:future, :root mjx-container { will-change: opacity; } mjx-math { display: inline-block; text-align: left; line-height: 0; text-indent: 0; font-style: normal; font-weight: normal; font-size: 100%; font-size-adjust: none; letter-spacing: normal; border-collapse: collapse; word-wrap: normal; word-spacing: normal; white-space: nowrap; direction: ltr; padding: 1px 0; } mjx-container[jax="CHTML"][display="true"] { display: block; text-align: center; margin: 1em 0; } mjx-container[jax="CHTML"][display="true"][width="full"] { display: flex; } mjx-container[jax="CHTML"][display="true"] mjx-math { padding: 0; } mjx-container[jax="CHTML"][justify="left"] { text-align: left; } mjx-container[jax="CHTML"][justify="right"] { text-align: right; } mjx-mi { display: inline-block; text-align: left; } mjx-c { display: inline-block; } mjx-utext { display: inline-block; padding: .75em 0 .2em 0; } mjx-mo { display: inline-block; text-align: left; } mjx-stretchy-h { display: inline-table; width: 100%; } mjx-stretchy-h > * { display: table-cell; width: 0; } mjx-stretchy-h > * > mjx-c { display: inline-block; transform: scalex(1.0000001); } mjx-stretchy-h > * > mjx-c::before { display: inline-block; width: initial; } mjx-stretchy-h > mjx-ext { /* IE */ overflow: hidden; /* others */ overflow: clip visible; width: 100%; } mjx-stretchy-h > mjx-ext > mjx-c::before { transform: scalex(500); } mjx-stretchy-h > mjx-ext > mjx-c { width: 0; } mjx-stretchy-h > mjx-beg > mjx-c { margin-right: -.1em; } mjx-stretchy-h > mjx-end > mjx-c { margin-left: -.1em; } mjx-stretchy-v { display: inline-block; } mjx-stretchy-v > * { display: block; } mjx-stretchy-v > mjx-beg { height: 0; } mjx-stretchy-v > mjx-end > mjx-c { display: block; } mjx-stretchy-v > * > mjx-c { transform: scaley(1.0000001); transform-origin: left center; overflow: hidden; } mjx-stretchy-v > mjx-ext { display: block; height: 100%; box-sizing: border-box; border: 0px solid transparent; /* IE */ overflow: hidden; /* others */ overflow: visible clip; } mjx-stretchy-v > mjx-ext > mjx-c::before { width: initial; box-sizing: border-box; } mjx-stretchy-v > mjx-ext > mjx-c {