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PSEBench introduces a novel, policy-grounded benchmark for evaluating large language models in high-stakes patient safety triage, addressing critical gaps in evidence-based reasoning and principled abstention. By utilizing a structured "clause card" methodology to generate auditable ground truths, the benchmark enables rigorous testing of 15 representative LLMs across 5,074 clinical cases. This work provides a scalable framework for assessing agentic capabilities in regulatory compliance, offering actionable insights for developers aiming to deploy reliable AI in healthcare workflows.
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PSEBench: A Controllable and Verifiable Benchmark for Evaluating LLMs in Patient Safety Event Triage

arXiv2 min read

arXiv:2606.05463v1 Announce Type: new Abstract: Patient safety event triage, determining whether a clinical event is reportable under jurisdiction-specific policy, is a high-stakes task typically performed manually by patient safety experts. Although LLMs may support this workflow, reliable evaluation is limited by the lack of benchmarks to capture evidence-grounded policy reasoning, proactive information seeking for incomplete reports, and principled abstention in irreducibly ambiguous cases. We address this gap with a policy-grounded construction methodology centered on the clause card, a structured representation that factorizes regulatory text into auditable decision specifications. Combining clause cards with anchor-driven instantiation and closed-loop verification, our scalable pipeline produces narratives with by-construction ground truth and naturally supports generating missing information and uncertain variants. We instantiate this method on Minnesota's 29 Reportable Adverse Health Events, producing PSEBench, a 5,074-case benchmark with an agentic evaluation environment. Evaluation on 15 representative LLMs reveals consistent capability trends, demonstrates the benchmark's utility, and identifies actionable gaps toward reliable LLM-based patient safety event triage.

Abstract:Patient safety event triage, determining whether a clinical event is reportable under jurisdiction-specific policy, is a high-stakes task typically performed manually by patient safety experts. Although LLMs may support this workflow, reliable evaluation is limited by the lack of benchmarks to capture evidence-grounded policy reasoning, proactive information seeking for incomplete reports, and principled abstention in irreducibly ambiguous cases. We address this gap with a policy-grounded construction methodology centered on the clause card, a structured representation that factorizes regulatory text into auditable decision specifications. Combining clause cards with anchor-driven instantiation and closed-loop verification, our scalable pipeline produces narratives with by-construction ground truth and naturally supports generating missing information and uncertain variants. We instantiate this method on Minnesota's 29 Reportable Adverse Health Events, producing PSEBench, a 5,074-case benchmark with an agentic evaluation environment. Evaluation on 15 representative LLMs reveals consistent capability trends, demonstrates the benchmark's utility, and identifies actionable gaps toward reliable LLM-based patient safety event triage.

Artificial Intelligence (cs.AI)

arXiv:2606.05463 [cs.AI]

(or arXiv:2606.05463v1 [cs.AI] for this version)

https://doi.org/10.48550/arXiv.2606.05463 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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Full text under the publisher's open licence · 249 words

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