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This research addresses the "semantic-interface gap" in Multimodal Large Language Models by introducing MedMLIP, a framework that pretrains visual encoders specifically for autoregressive LLM interfaces rather than relying on standard CLIP features. By employing Local Relational Distillation to preserve patch relationships, the study demonstrates improved cross-LLM transferability and fine-grained visual information retention in medical imaging tasks. The work provides a critical methodological advance for optimizing vision-language alignment within specialized MLLL architectures.
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Pretraining of Medical Visual Encoders Toward Multi-modal Large Language Models

arXiv2 min read

arXiv:2609.23860v1 Announce Type: new Abstract: Multimodal Large Language Models (MLLMs) commonly reuse visual encoders pretrained with CLIP, although the features of these ViTs are ultimately consumed by autoregressive LLMs. We refer to this mismatch as the semantic-interface gap and introduce MedMLIP, a framework that pretrains the visual encoder through report generation with a frozen LLM, while employing Local Relational Distillation (LRD) to preserve relationships among visual patches to avoid visual collapse. We pretrain MedMLIP on IU-Xray and Open-PMC-300K and evaluate the resulting encoders on VQA-RAD and SLAKE. Only the ViT is transferred, while the guiding LLM and projector are replaced, allowing us to assess cross-LLM transferability. Our cross-LLM transfer experiments demonstrate the value of pretraining visual encoders for their autoregressive LLM interface while trying to preserve more fine-grained visual information. Code and the pretrained model are available at https://github.com/SkyCol/MedMLIP

Abstract:Multimodal Large Language Models (MLLMs) commonly reuse visual encoders pretrained with CLIP, although the features of these ViTs are ultimately consumed by autoregressive LLMs. We refer to this mismatch as the semantic-interface gap and introduce MedMLIP, a framework that pretrains the visual encoder through report generation with a frozen LLM, while employing Local Relational Distillation (LRD) to preserve relationships among visual patches to avoid visual collapse. We pretrain MedMLIP on IU-Xray and Open-PMC-300K and evaluate the resulting encoders on VQA-RAD and SLAKE. Only the ViT is transferred, while the guiding LLM and projector are replaced, allowing us to assess cross-LLM transferability. Our cross-LLM transfer experiments demonstrate the value of pretraining visual encoders for their autoregressive LLM interface while trying to preserve more fine-grained visual information. Code and the pretrained model are available at this https URL

Artificial Intelligence (cs.AI)

arXiv:2609.23860 [cs.AI]

(or arXiv:2609.23860v1 [cs.AI] for this version)

https://doi.org/10.48550/arXiv.2609.23860 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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Full text under the publisher's open licence · 230 words

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