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This research introduces Physics-Enabled Evidential Learning (PEEL) to resolve parameter identifiability issues in CT imaging by integrating physical measurements with deep learning models. The approach successfully estimates aleatoric uncertainty using a frozen network and Monte Carlo propagation, achieving high correlation with reference data without relying on standard regularization terms like KL divergence. By leveraging physics-informed constraints, the method provides more robust uncertainty quantification for medical imaging tasks where statistical likelihoods alone are insufficient.
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PEEL: Physics-Enabled Evidential Learning for Identifiable Uncertainty in CT Imaging

arXiv2 min read

arXiv:2609.29599v1 Announce Type: new Abstract: Normal-inverse-gamma (NIG) regression is not uniquely identifiable from its marginal Student-t likelihood: the likelihood determines three combinations of four NIG parameters and is constant along a one-dimensional fiber. We identify that fiber using independent physical measurement. As an initial embodiment, a reconstruction network receives one noisy filtered-backprojection (FBP) image and is first trained only by Student-t negative log-likelihood to estimate the three identifiable coordinates (gamma, alpha, c). The network is then frozen; repeated physical-noise realizations propagated through its reconstruction output form a Monte Carlo (MC) teacher label for output-domain aleatoric variance. An aleatoric head attached to frozen features learns this label, after which (beta, nu) are recovered algebraically. On 30 held-out simulated objects at five photon levels, one-image predictions achieved pooled Spearman correlations of 0.832-0.951 against independent 400-repeat references, median within-image correlations were 0.834-0.947, and 98.81-99.55% of evaluated pixels satisfied the algebraic admissibility condition. The method needs no KL term, reference prior, evidence regularizer, or cross-loss weight.

Abstract:Normal-inverse-gamma (NIG) regression is not uniquely identifiable from its marginal Student-t likelihood: the likelihood determines three combinations of four NIG parameters and is constant along a one-dimensional fiber. We identify that fiber using independent physical measurement. As an initial embodiment, a reconstruction network receives one noisy filtered-backprojection (FBP) image and is first trained only by Student-t negative log-likelihood to estimate the three identifiable coordinates (gamma, alpha, c). The network is then frozen; repeated physical-noise realizations propagated through its reconstruction output form a Monte Carlo (MC) teacher label for output-domain aleatoric variance. An aleatoric head attached to frozen features learns this label, after which (beta, nu) are recovered algebraically. On 30 held-out simulated objects at five photon levels, one-image predictions achieved pooled Spearman correlations of 0.832-0.951 against independent 400-repeat references, median within-image correlations were 0.834-0.947, and 98.81-99.55% of evaluated pixels satisfied the algebraic admissibility condition. The method needs no KL term, reference prior, evidence regularizer, or cross-loss weight.

10 pages, 3 figures, 1 table. Proof-of-concept study of physics-enabled identification of NIG uncertainty in CT imaging

Artificial Intelligence (cs.AI); Medical Physics (physics.med-ph)

arXiv:2609.29599 [cs.AI]

(or arXiv:2609.29599v1 [cs.AI] for this version)

https://doi.org/10.48550/arXiv.2609.29599 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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Full text under the publisher's open licence · 271 words

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