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This research addresses parameter recovery in multivariate Ornstein-Uhlenbeck processes using steady-state data, a critical capability for analyzing large-scale gene perturbation experiments where time-series trajectories are unavailable. The authors establish theoretical bounds showing that a single intervention per strongly connected component is sufficient for identifiability and introduce a recursive algorithm to solve the resulting linear systems. While the mathematical framework relies on stochastic differential equations, its application to biological networks represents a significant advancement in machine learning methods for inferring causal dynamics from limited observational data.
One Intervention per Component is Enough: Towards Identifiability in Linear Stochastic Dynamics from Steady State
arXiv:2609.19955v1 Announce Type: new Abstract: We study the problem of recovering the parameters of a multivariate Ornstein-Uhlenbeck (OU) process from steady-state observational and interventional data. In many applications, such as large-scale gene perturbation experiments, only stationary "snapshot" measurements are available, making standard stochastic differential equation estimation methods that rely on time-series trajectories inapplicable. We first establish an identifiability result: one intervention per strongly connected component (SCC) of the drift graph suffices to recover all OU process parameters generically up to a global scaling factor. This holds provided that the SCC condensation graph is connected with a single root and certain spectral nondegeneracy assumptions hold. We propose a recursive learning algorithm that orders SCCs topologically and, for each component, isolates its marginal dynamics and solves a linear system derived from the steady-state moment equations, leveraging parameters recovered for upstream components. Building on this theoretical foundation, we propose a regularized least-squares estimator that jointly minimizes residuals of the steady-state mean and covariance equations across observational and interventional data. Experimental results validate our theoretical findings in recovering parameters of the underlying OU process.
Abstract:We study the problem of recovering the parameters of a multivariate Ornstein-Uhlenbeck (OU) process from steady-state observational and interventional data. In many applications, such as large-scale gene perturbation experiments, only stationary "snapshot" measurements are available, making standard stochastic differential equation estimation methods that rely on time-series trajectories inapplicable. We first establish an identifiability result: one intervention per strongly connected component (SCC) of the drift graph suffices to recover all OU process parameters generically up to a global scaling factor. This holds provided that the SCC condensation graph is connected with a single root and certain spectral nondegeneracy assumptions hold. We propose a recursive learning algorithm that orders SCCs topologically and, for each component, isolates its marginal dynamics and solves a linear system derived from the steady-state moment equations, leveraging parameters recovered for upstream components. Building on this theoretical foundation, we propose a regularized least-squares estimator that jointly minimizes residuals of the steady-state mean and covariance equations across observational and interventional data. Experimental results validate our theoretical findings in recovering parameters of the underlying OU process.
Machine Learning (cs.LG)
arXiv:2609.19955 [cs.LG]
(or arXiv:2609.19955v1 [cs.LG] for this version)
https://doi.org/10.48550/arXiv.2609.19955 Focus to learn more arXiv-issued DOI via DataCite (pending registration)
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