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This research introduces HypoAgent, an agentic framework that refines abductive reasoning over knowledge graphs by iteratively diagnosing mismatches between generated hypotheses and observed data. By treating condition signals as operators rather than just intent expressions, the system enables reliable revision of discrete logical structures, overcoming the limitations of single-shot generation in large language models. The approach demonstrates improved performance on biomedical and general knowledge graph benchmarks, advancing the reliability of automated reasoning systems.
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One Hypothesis Is Not Enough: Abductive Reasoning with Agentic Hypothesis Refinement over Knowledge Graphs

arXiv3 min read

arXiv:2605.31370v2 Announce Type: replace Abstract: Abductive reasoning over knowledge graphs (KGs) seeks a first-order logic hypothesis whose answer set explains a given set of observed entities. Since many hypotheses can explain the same observations, controllable hypothesis generators condition generation on entities, relations, or logical patterns, but they treat generation as a single step. A generated hypothesis may be well-formed and satisfy the given conditions yet still fail to explain the observations, and the model has no mechanism to detect or correct this mismatch. Closing the abductive cycle requires revising a discrete, structured hypothesis, which large language models cannot do reliably, even though they iterate readily in natural language. We propose HypoAgent, an agentic hypothesis refinement framework that treats condition signals not only as expressions of user intent but also as operators that steer generation. A Hypothesis Proposal Agent calls a small trained generator to propose a hypothesis. Root-cause analysis then uses fragment-level coverage to locate branches worth inspecting and gathers neighborhood evidence from the training graph. A Hypothesis Refiner Agent combines this diagnosis with previously generated hypotheses to produce updated conditions and directly revised hypotheses. HypoAgent outperforms one-shot generation in single-turn and multi-turn settings on BioKG, PharmKG8k, and DBpedia50, and in the unconditional setting on DBpedia50. Our code is available at https://github.com/HKUST-KnowComp/HypoAgent.

Abstract:Abductive reasoning over knowledge graphs (KGs) seeks a first-order logic hypothesis whose answer set explains a given set of observed entities. Since many hypotheses can explain the same observations, controllable hypothesis generators condition generation on entities, relations, or logical patterns, but they treat generation as a single step. A generated hypothesis may be well-formed and satisfy the given conditions yet still fail to explain the observations, and the model has no mechanism to detect or correct this mismatch. Closing the abductive cycle requires revising a discrete, structured hypothesis, which large language models cannot do reliably, even though they iterate readily in natural language. We propose HypoAgent, an agentic hypothesis refinement framework that treats condition signals not only as expressions of user intent but also as operators that steer generation. A Hypothesis Proposal Agent calls a small trained generator to propose a hypothesis. Root-cause analysis then uses fragment-level coverage to locate branches worth inspecting and gathers neighborhood evidence from the training graph. A Hypothesis Refiner Agent combines this diagnosis with previously generated hypotheses to produce updated conditions and directly revised hypotheses. HypoAgent outperforms one-shot generation in single-turn and multi-turn settings on BioKG, PharmKG8k, and DBpedia50, and in the unconditional setting on DBpedia50. Our code is available at this https URL.

Artificial Intelligence (cs.AI)

arXiv:2605.31370 [cs.AI]

(or arXiv:2605.31370v2 [cs.AI] for this version)

https://doi.org/10.48550/arXiv.2605.31370 Focus to learn more arXiv-issued DOI via DataCite

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