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This research introduces MAC-RRG, an iterative multi-agent framework designed to address hallucinations and improve interpretability in X-ray radiology report generation by dynamically fusing structured and unstructured medical knowledge. The approach decouples tasks between a vision encoder, dual specialized agents, and a large language model to create a closed-loop optimization paradigm for refining diagnostic reports. By moving beyond static knowledge fusion, this work advances the practical deployment of LLMs in high-stakes clinical settings where accuracy and reasoning transparency are critical.
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MAC-RRG: Iterative Multi-Agent Collaboration for X-ray Radiology Report Generation

arXiv3 min read

arXiv:2609.26124v1 Announce Type: new Abstract: Despite the remarkable progress of LLM-based and knowledge graph-augmented Radiology Report Generation (RRG) methods, existing techniques still suffer from inherent defects. Conventional LLM-only models lack structured medical prior knowledge, resulting in frequent medical hallucinations and low diagnostic interpretability. Current knowledge graph-enhanced schemes adopt static one-round knowledge fusion with single-source knowledge, incapable of dynamic knowledge updating according to generation feedback. This paper proposes a novel Multi-Agent Collaborative iterative framework for X-ray Radiology Report Generation, termed MAC-RRG. Inspired by multi-agent technology, our framework constructs a closed-loop optimization paradigm based on task decoupling and collaborative reasoning. Specifically, the framework first generates a preliminary radiology report from input X-ray images via a vision encoder and a basic LLM. Subsequently, a multimodal knowledge graph (MM-KG) agent mines structured disease correlation and anatomical knowledge from medical knowledge graphs, while an auxiliary knowledge agent extracts unstructured domain knowledge from public medical databases. The multi-source knowledge acquired by dual agents is fused and embedded to guide the LLM in iteratively refining the initial report. Extensive quantitative and qualitative experiments on mainstream X-ray RRG datasets, including IU X-ray, MIMIC, and CheXpert Plus, fully verify the superiority of our proposed method. The source code and pre-trained models have been released on https://github.com/Event-AHU/Medical_Image_Analysis

Abstract:Despite the remarkable progress of LLM-based and knowledge graph-augmented Radiology Report Generation (RRG) methods, existing techniques still suffer from inherent defects. Conventional LLM-only models lack structured medical prior knowledge, resulting in frequent medical hallucinations and low diagnostic interpretability. Current knowledge graph-enhanced schemes adopt static one-round knowledge fusion with single-source knowledge, incapable of dynamic knowledge updating according to generation feedback. This paper proposes a novel Multi-Agent Collaborative iterative framework for X-ray Radiology Report Generation, termed MAC-RRG. Inspired by multi-agent technology, our framework constructs a closed-loop optimization paradigm based on task decoupling and collaborative reasoning. Specifically, the framework first generates a preliminary radiology report from input X-ray images via a vision encoder and a basic LLM. Subsequently, a multimodal knowledge graph (MM-KG) agent mines structured disease correlation and anatomical knowledge from medical knowledge graphs, while an auxiliary knowledge agent extracts unstructured domain knowledge from public medical databases. The multi-source knowledge acquired by dual agents is fused and embedded to guide the LLM in iteratively refining the initial report. Extensive quantitative and qualitative experiments on mainstream X-ray RRG datasets, including IU X-ray, MIMIC, and CheXpert Plus, fully verify the superiority of our proposed method. The source code and pre-trained models have been released on this https URL

Artificial Intelligence (cs.AI)

arXiv:2609.26124 [cs.AI]

(or arXiv:2609.26124v1 [cs.AI] for this version)

https://doi.org/10.48550/arXiv.2609.26124 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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Full text under the publisher's open licence · 298 words

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