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This study exposes critical blind spots in agentic LLM pipelines used for medical data harmonization, demonstrating that high label agreement scores can mask failures in authorization, output completeness, and evidence sensitivity. The authors reveal that standard metrics fail to detect downstream errors like row-order issues that erase diagnostic signals, necessitating separate audits of commitment and action validity rather than relying on aggregate consistency. For AI practitioners deploying autonomous agents in regulated domains, this work underscores the urgent need for granular validation protocols that distinguish between mere label matching and actionable, authorized outputs.
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Label Agreement Does Not Measure Authorization

arXiv3 min read

arXiv:2610.04544v1 Announce Type: new Abstract: Many groups now delegate label ontology and metadata harmonization to agentic LLM pipelines. We built one and audited it. Our aggregate scores looked healthy, but the pipeline kept failing in ways they did not show, so we set out to find what they hid. Label agreement asks whether a proposed label matches a reference. It does not ask whether the agent was entitled to propose it, whether the output was complete enough to act on, or whether the label moved when the evidence moved. We measured those three separately on COBRE and FBIRN, two schizophrenia and control neuroimaging cohorts from different consortia, and they come apart, from label agreement and from each other. Showing the agent an upstream proposal barely moves label agreement, 0.857 to 0.870, while agreement on the chosen action doubles, 0.409 to 0.830. Output that parses as JSON still drops a required field on 10% of one model's cases and 33% of the other's. And an agent that replays its first answer scores perfectly on original cases and zero once we change the evidence that decides them. Downstream, a row-order error that none of these metrics reports erases most of the diagnostic signal. So we measure these properties apart, pair each with a control, and gate commitment on the result, which makes failures visible and easy to route to a person. None of this prevents failure. Our reference labels are rule-derived, so agreement with them means consistency, not correctness. Code is available at https://github.com/amir-sbg/Label-Agreement-Does-Not-Measure-Authorization.

Abstract:Many groups now delegate label ontology and metadata harmonization to agentic LLM pipelines. We built one and audited it. Our aggregate scores looked healthy, but the pipeline kept failing in ways they did not show, so we set out to find what they hid. Label agreement asks whether a proposed label matches a reference. It does not ask whether the agent was entitled to propose it, whether the output was complete enough to act on, or whether the label moved when the evidence moved. We measured those three separately on COBRE and FBIRN, two schizophrenia and control neuroimaging cohorts from different consortia, and they come apart, from label agreement and from each other. Showing the agent an upstream proposal barely moves label agreement, 0.857 to 0.870, while agreement on the chosen action doubles, 0.409 to 0.830. Output that parses as JSON still drops a required field on 10% of one model's cases and 33% of the other's. And an agent that replays its first answer scores perfectly on original cases and zero once we change the evidence that decides them. Downstream, a row-order error that none of these metrics reports erases most of the diagnostic signal. So we measure these properties apart, pair each with a control, and gate commitment on the result, which makes failures visible and easy to route to a person. None of this prevents failure. Our reference labels are rule-derived, so agreement with them means consistency, not correctness. Code is available at this https URL.

Artificial Intelligence (cs.AI); Machine Learning (cs.LG)

arXiv:2610.04544 [cs.AI]

(or arXiv:2610.04544v1 [cs.AI] for this version)

https://doi.org/10.48550/arXiv.2610.04544 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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Full text under the publisher's open licence · 346 words

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