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LabAgent addresses the critical challenge of scientific knowledge inheritance by enabling AI agents to autonomously reproduce and expand upon complex laboratory methods across life science domains. By outperforming commercial generalist agents in tasks ranging from drug property prediction to protein variant analysis, this system offers a robust framework for maintaining research continuity despite personnel changes. The technology represents a significant step toward autonomous, self-correcting research environments that can reliably verify and build upon prior scientific efforts.
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LabAgent: Customize Any Research Hubs for Scientific Discoveries Using AI Agents

arXiv2 min read

arXiv:2609.13437v1 Announce Type: new Abstract: Scientific research is a continuous process that emphasizes inheritance. Methods developed by predecessors are often expanded upon by new researchers to explore more novel and in-depth scientific questions. However, the change of lab staff, such as student graduation, leads to a lack of personnel capable of replicating methods. Methods that have been developed with significant effort and resources cannot be continued. To address these limitations, we propose LabAgent, a reproduce and discovery harness tailored for a lab's continuous work. LabAgent employs two mechanisms to guarantee that all skills can be executed and verified and to record the corrective methods and experiences, allowing for direct correction or avoidance of similar errors. We applied LabAgent to drug property prediction, biomedical problem analysis, protein variant effect prediction, and statistical genetics in life science domains. LabAgent ranks first over commercial generalist agents in every domain, and demonstrates accurate reproduction of a published figure. Overall, these results demonstrate that LabAgent can effectively integrate and reasonably expand laboratory knowledge.

Abstract:Scientific research is a continuous process that emphasizes inheritance. Methods developed by predecessors are often expanded upon by new researchers to explore more novel and in-depth scientific questions. However, the change of lab staff, such as student graduation, leads to a lack of personnel capable of replicating methods. Methods that have been developed with significant effort and resources cannot be continued. To address these limitations, we propose LabAgent, a reproduce and discovery harness tailored for a lab's continuous work. LabAgent employs two mechanisms to guarantee that all skills can be executed and verified and to record the corrective methods and experiences, allowing for direct correction or avoidance of similar errors. We applied LabAgent to drug property prediction, biomedical problem analysis, protein variant effect prediction, and statistical genetics in life science domains. LabAgent ranks first over commercial generalist agents in every domain, and demonstrates accurate reproduction of a published figure. Overall, these results demonstrate that LabAgent can effectively integrate and reasonably expand laboratory knowledge.

Artificial Intelligence (cs.AI); Biomolecules (q-bio.BM)

arXiv:2609.13437 [cs.AI]

(or arXiv:2609.13437v1 [cs.AI] for this version)

https://doi.org/10.48550/arXiv.2609.13437 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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Full text under the publisher's open licence · 259 words

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