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HypEHR introduces a compact Lorentzian model specifically designed to leverage the inherent hyperbolic geometry of medical ontologies and patient trajectories, offering an efficient alternative to resource-intensive LLM pipelines for electronic health record question answering. By aligning representations with ICD ontology structures through hierarchy-aware regularization, this approach achieves performance comparable to large language models while significantly reducing parameter count and deployment costs.
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HypEHR: Hyperbolic Modeling of Electronic Health Records for Efficient Question Answering

arXiv2 min read

arXiv:2604.21027v2 Announce Type: replace Abstract: Electronic health record (EHR) question answering is often handled by LLM-based pipelines that are costly to deploy and do not explicitly leverage the hierarchical structure of clinical data. Motivated by evidence that medical ontologies and patient trajectories exhibit hyperbolic geometry, we propose HypEHR, a compact Lorentzian model that embeds codes, visits, and questions in hyperbolic space and answers queries via geometry-consistent cross-attention with type-specific pointer heads. HypEHR is pretrained with next-visit diagnosis prediction and hierarchy-aware regularization to align representations with the ICD ontology. On two MIMIC-IV-based EHR-QA benchmarks, HypEHR approaches LLM-based methods while using far fewer parameters. Our code is publicly available at https://github.com/yuyuliu11037/HypEHR.

Abstract:Electronic health record (EHR) question answering is often handled by LLM-based pipelines that are costly to deploy and do not explicitly leverage the hierarchical structure of clinical data. Motivated by evidence that medical ontologies and patient trajectories exhibit hyperbolic geometry, we propose HypEHR, a compact Lorentzian model that embeds codes, visits, and questions in hyperbolic space and answers queries via geometry-consistent cross-attention with type-specific pointer heads. HypEHR is pretrained with next-visit diagnosis prediction and hierarchy-aware regularization to align representations with the ICD ontology. On two MIMIC-IV-based EHR-QA benchmarks, HypEHR approaches LLM-based methods while using far fewer parameters. Our code is publicly available at this https URL.

Artificial Intelligence (cs.AI)

arXiv:2604.21027 [cs.AI]

(or arXiv:2604.21027v2 [cs.AI] for this version)

https://doi.org/10.48550/arXiv.2604.21027 Focus to learn more arXiv-issued DOI via DataCite

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