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This research introduces an unbiased test-time guidance framework using Density Ratio Estimation (DRE) to overcome the prior dependency limitations of existing Simulation-Based Inference methods. By decoupling inference from training priors, the approach offers improved flexibility and robustness for scientific parameter estimation tasks where prior knowledge evolves. The method demonstrates superior performance over current baselines like PriorGuide while remaining agnostic to specific density ratio estimators.
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Guidance for Prior Change via Density Ratio Estimation

arXiv3 min read

arXiv:2608.21729v1 Announce Type: cross Abstract: Simulation-Based Inference (SBI) serves as a vital framework for parameter inference in scientific fields where simulators involve intractable likelihoods, yet while amortized generative models offer rapid posterior estimation, they are often restricted by the specific priors used during training, thereby limiting their flexibility as prior knowledge evolves. To address this prior dependency, PriorGuide was introduced as an inference-time guidance method, but due to its intractable formulation, it relies on Gaussian approximations of the reverse transition kernel and Gaussian mixture model fitting for the prior ratio, both of which introduce systematic bias. Motivated by these limitations, we propose an unbiased test-time guidance framework that leverages Density Ratio Estimation (DRE) to learn a score guidance term, effectively decoupling the inference process from the prior training. Moreover, our framework remains agnostic to the specific density ratio estimators, making it a general and flexible framework for handling prior changes. Experimental results across multiple tasks demonstrate that our method matches or outperforms PriorGuide on C2ST and MMD in most tasks while maintaining robustness even under limited overlap between the training and target priors. Furthermore, we apply our method to Bayesian updating for parameter inference from planetary light-curve data, where it also demonstrates strong effectiveness and robustness. Code is available at https://github.com/a-chenchen/dre-based-prior-guidance .

Abstract:Simulation-Based Inference (SBI) serves as a vital framework for parameter inference in scientific fields where simulators involve intractable likelihoods, yet while amortized generative models offer rapid posterior estimation, they are often restricted by the specific priors used during training, thereby limiting their flexibility as prior knowledge evolves. To address this prior dependency, PriorGuide was introduced as an inference-time guidance method, but due to its intractable formulation, it relies on Gaussian approximations of the reverse transition kernel and Gaussian mixture model fitting for the prior ratio, both of which introduce systematic bias. Motivated by these limitations, we propose an unbiased test-time guidance framework that leverages Density Ratio Estimation (DRE) to learn a score guidance term, effectively decoupling the inference process from the prior training. Moreover, our framework remains agnostic to the specific density ratio estimators, making it a general and flexible framework for handling prior changes. Experimental results across multiple tasks demonstrate that our method matches or outperforms PriorGuide on C2ST and MMD in most tasks while maintaining robustness even under limited overlap between the training and target priors. Furthermore, we apply our method to Bayesian updating for parameter inference from planetary light-curve data, where it also demonstrates strong effectiveness and robustness. Code is available at this https URL .

Machine Learning (stat.ML); Machine Learning (cs.LG); Methodology (stat.ME)

arXiv:2608.21729 [stat.ML]

(or arXiv:2608.21729v1 [stat.ML] for this version)

https://doi.org/10.48550/arXiv.2608.21729 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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Full text under the publisher's open licence · 308 words

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