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This research applies machine learning architectures to classify suspected overdose deaths from investigation reports, demonstrating that explainable pipeline models outperform existing rule-based systems by 15%. The study highlights the practical utility of AI in public health workflows where interpretability and expert-in-the-loop design are critical for deployment.
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Evidence-Anchored Overdose Death Prediction from Death Investigation Reports

arXiv2 min read

arXiv:2610.19556v1 Announce Type: new Abstract: Confirmation of overdose deaths in the United States is often delayed due to the complexities of certifying drug-involved deaths. Death investigation reports represent a rich but underutilized data source that could be used to predict whether a death is a suspected overdose (i.e., a death preliminarily identified as an overdose prior to the final cause and manner of death determination). We present an automated framework that classifies suspected overdoses from death investigation reports, while producing supporting explanations guided by expert knowledge. Through an expert-guided design process, we investigate 1) what type of explanations are best for model prediction performance, and 2) which architecture is better suited for this task: pipeline models that rationalize first and then predict, or self-rationalizing models that jointly predict and rationalize? Our experiments show that a pipeline model with explanations grounded in the input death investigation reports outperforms the other settings. Our best model also outperforms a rule-based system currently in deployment by 15%, while allowing expert interventions for final decisions.

Authors:Raavi Gupta, Ziqing Yang, Karli R. Hochstatter, Talia Nadel, Nicole D'Anna, Jason K. Graham, Hannah Johnson, Kelsey Opozda, Nabila El-Bassel, Anubhav Jangra, Smaranda Muresan

Abstract:Confirmation of overdose deaths in the United States is often delayed due to the complexities of certifying drug-involved deaths. Death investigation reports represent a rich but underutilized data source that could be used to predict whether a death is a suspected overdose (i.e., a death preliminarily identified as an overdose prior to the final cause and manner of death determination). We present an automated framework that classifies suspected overdoses from death investigation reports, while producing supporting explanations guided by expert knowledge. Through an expert-guided design process, we investigate 1) what type of explanations are best for model prediction performance, and 2) which architecture is better suited for this task: pipeline models that rationalize first and then predict, or self-rationalizing models that jointly predict and rationalize? Our experiments show that a pipeline model with explanations grounded in the input death investigation reports outperforms the other settings. Our best model also outperforms a rule-based system currently in deployment by 15%, while allowing expert interventions for final decisions.

Computation and Language (cs.CL); Artificial Intelligence (cs.AI); Machine Learning (cs.LG)

arXiv:2610.19556 [cs.CL]

(or arXiv:2610.19556v1 [cs.CL] for this version)

https://doi.org/10.48550/arXiv.2610.19556 arXiv-issued DOI via DataCite (pending registration)

Full text under the publisher's open licence · 214 words

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