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DoctorAgents introduces a novel agentic framework using LLMs to replace brute-force search with reasoning-driven refinement in automated machine learning pipelines, specifically targeting scarce clinical temporal data. By utilizing textual gradient descent and specialized agents for validation, the system achieves superior performance and interpretability compared to traditional AutoML baselines without requiring exhaustive hyperparameter searches. This approach represents a significant methodological shift toward memory-equipped, reason-based optimization within high-stakes medical AI applications.
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DoctorAgents: an agentic framework to iteratively refine AutoML pipeline for small clinical temporal data

arXiv2 min read

arXiv:2608.05375v1 Announce Type: cross Abstract: Clinical machine learning (ML) has the potential to support high-stakes medical decision-making, but reliable deployment is often constrained by scarce, heterogeneous, and temporal complexity. Developing effective ML pipelines for such data remains time-consuming and error-prone, while existing automated machine learning (AutoML) systems only partially address this challenge because they largely rely on brute-force search over predefined spaces and lack explicit reasoning and memory. We therefore reformulate AutoML for small clinical data from exhaustive search to reasoning-driven refinement. We propose DoctorAgents, an agentic AI framework that autonomously constructs and optimizes end-to-end ML pipelines through specialized large language model (LLM) agents for generation, validation, and refinement. DoctorAgents backpropagates natural-language feedback through textual gradient descent to perform targeted updates without exhaustive search. Experiments across diverse clinical tasks show that DoctorAgents consistently outperforms established AutoML baselines while producing more interpretable task-specific representations.

Abstract:Clinical machine learning (ML) has the potential to support high-stakes medical decision-making, but reliable deployment is often constrained by scarce, heterogeneous, and temporal complexity. Developing effective ML pipelines for such data remains time-consuming and error-prone, while existing automated machine learning (AutoML) systems only partially address this challenge because they largely rely on brute-force search over predefined spaces and lack explicit reasoning and memory. We therefore reformulate AutoML for small clinical data from exhaustive search to reasoning-driven refinement. We propose DoctorAgents, an agentic AI framework that autonomously constructs and optimizes end-to-end ML pipelines through specialized large language model (LLM) agents for generation, validation, and refinement. DoctorAgents backpropagates natural-language feedback through textual gradient descent to perform targeted updates without exhaustive search. Experiments across diverse clinical tasks show that DoctorAgents consistently outperforms established AutoML baselines while producing more interpretable task-specific representations.

Artificial Intelligence (cs.AI); Machine Learning (cs.LG); Multiagent Systems (cs.MA)

arXiv:2608.05375 [cs.AI]

(or arXiv:2608.05375v1 [cs.AI] for this version)

https://doi.org/10.48550/arXiv.2608.05375 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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Full text under the publisher's open licence · 238 words

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