Disentangling Acoustic Cues in Alzheimer's Pathology and Perception: The Roles of Language and Gender

Abstract:Acoustic biomarkers show promise for detecting Alzheimer's Disease (AD), yet whether the cues driving diagnostic AI align with those salient to human listeners is underexplored across languages and genders, where pathological markers and perceptual strategies differ. We train models to predict clinical AD status (pathology) and human perceptual scores across Mandarin and Greek, male and female speakers. Using SHAP for interpretability and statistical models for validation, we compare feature importance by subgroup. Results reveal a context-dependent divergence: pathological-perceptual alignment is significant for Mandarin and female speakers but disappears for Greek and male speakers, where pathology models did not exceed chance; this is a failure mode that population-specific auditing surfaces. Global Explainable AI (XAI) explanations can mask critical demographic divergences, highlighting the need for population-specific explainability auditing for equitable deployment of clinical speech AI.

Sound (cs.SD); Machine Learning (cs.LG)

arXiv:2607.23977 [cs.SD]

(or arXiv:2607.23977v1 [cs.SD] for this version)

https://doi.org/10.48550/arXiv.2607.23977 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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