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This research addresses the challenge of quantifying agreement among annotators using open-ended, unstructured text in biomedical literature—a critical step toward reliable knowledge extraction from scientific texts. The study evaluates various semantic equivalence measures and natural language inference approaches to determine which best balance scalability with accuracy when differentiating similar concepts. While large language models show promise for this task, the paper highlights their current limitations regarding chance agreement estimation at scale.
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Consensus Measures for Unstructured Biomedical Text Annotations

arXiv2 min read

arXiv:2608.03529v1 Announce Type: new Abstract: Biomedical literature is increasingly mined for knowledge beyond the questions it was written to answer. Because the target concepts are not known in advance, annotators prefer open-ended labels, whose agreement is hard to quantify. We study soft inter-rater reliability for annotators providing unstructured texts for biomedical annotation tasks. Synthetic experiments show that soft reliability can be quantified using a variety of semantic equivalence measures, and that the choice of measure affects failure modes of the estimation. Embeddings are scalable, but limited when differentiating similar but distinct concepts. Large language models are promising, but limited by scalability for estimating agreement by chance. Finally, we suggest measures based on natural language inference as a sensible compromise.

Abstract:Biomedical literature is increasingly mined for knowledge beyond the questions it was written to answer. Because the target concepts are not known in advance, annotators prefer open-ended labels, whose agreement is hard to quantify. We study soft inter-rater reliability for annotators providing unstructured texts for biomedical annotation tasks. Synthetic experiments show that soft reliability can be quantified using a variety of semantic equivalence measures, and that the choice of measure affects failure modes of the estimation. Embeddings are scalable, but limited when differentiating similar but distinct concepts. Large language models are promising, but limited by scalability for estimating agreement by chance. Finally, we suggest measures based on natural language inference as a sensible compromise.

Computation and Language (cs.CL)

arXiv:2608.03529 [cs.CL]

(or arXiv:2608.03529v1 [cs.CL] for this version)

https://doi.org/10.48550/arXiv.2608.03529 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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Full text under the publisher's open licence · 209 words

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