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ClinicalBench benchmarking reveals that current LLMs, despite their strengths in text processing, still fail to outperform traditional ML models like SVM and XGBoost in clinical prediction tasks. This empirical evidence highlights a critical gap in LLMs' clinical reasoning and decision-making capabilities, urging practitioners to exercise caution before deploying them in real-world healthcare settings. The study underscores that superior performance on licensing exams does not translate to superior predictive accuracy for complex medical tasks.
Source coveringarXiv

ClinicalBench: Can LLMs Beat Traditional ML Models in Clinical Prediction?

arXiv2 min read

arXiv:2411.06469v2 Announce Type: replace Abstract: Large Language Models (LLMs) hold great promise to revolutionize current clinical systems for their superior capacities on medical text processing tasks and medical licensing exams. Meanwhile, traditional ML models such as SVM and XGBoost have still been mainly adopted in clinical prediction tasks. An emerging question is: Can LLMs beat traditional ML models in clinical prediction? Thus, we build a new benchmark ClinicalBench to comprehensively study the clinical predictive modeling capacities of both general-purpose and medical LLMs, and compare them with traditional ML models. ClinicalBench embraces three common clinical prediction tasks, two databases, 14 general-purpose LLMs, 8 medical LLMs, and 11 traditional ML models. Through extensive empirical investigation, we discover that both general-purpose and medical LLMs, even with different model scales, diverse prompting or fine-tuning strategies, still cannot beat traditional ML models in clinical prediction yet, shedding light on their potential deficiency in clinical reasoning and decision-making. We call for caution when practitioners adopt LLMs in clinical applications. ClinicalBench can be utilized to bridge the gap between LLMs' development for healthcare and real-world clinical practice.

Abstract:Large Language Models (LLMs) hold great promise to revolutionize current clinical systems for their superior capacities on medical text processing tasks and medical licensing exams. Meanwhile, traditional ML models such as SVM and XGBoost have still been mainly adopted in clinical prediction tasks. An emerging question is: Can LLMs beat traditional ML models in clinical prediction? Thus, we build a new benchmark ClinicalBench to comprehensively study the clinical predictive modeling capacities of both general-purpose and medical LLMs, and compare them with traditional ML models. ClinicalBench embraces three common clinical prediction tasks, two databases, 14 general-purpose LLMs, 8 medical LLMs, and 11 traditional ML models. Through extensive empirical investigation, we discover that both general-purpose and medical LLMs, even with different model scales, diverse prompting or fine-tuning strategies, still cannot beat traditional ML models in clinical prediction yet, shedding light on their potential deficiency in clinical reasoning and decision-making. We call for caution when practitioners adopt LLMs in clinical applications. ClinicalBench can be utilized to bridge the gap between LLMs' development for healthcare and real-world clinical practice.

Accepted to Proceedings of KDD 2026. The first two authors contributed equally. 12 pages for main paper, 62 pages including appendix. Project website: this https URL

Computation and Language (cs.CL)

arXiv:2411.06469 [cs.CL]

(or arXiv:2411.06469v2 [cs.CL] for this version)

Full text under the publisher's open licence · 213 words