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This research introduces EvidenceNet, a structured dataset derived from full-text biomedical literature that leverages LLMs to extract high-fidelity evidence records into graph representations. By preserving study design and provenance rather than compressing data into flat triples, the system enables more robust retrieval-augmented generation and graph-based reasoning tasks in specialized medical domains. The release establishes a new benchmark for evidence-aware analysis, demonstrating that structured extraction from unstructured text significantly improves downstream AI performance in biomedical contexts.
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Building evidence-based knowledge bases from full-text literature for disease-specific biomedical reasoning

arXiv2 min read

arXiv:2603.28325v4 Announce Type: replace-cross Abstract: Biomedical knowledge resources often either preserve evidence as unstructured text or compress it into flat triples that omit study design, provenance, and quantitative support. Here we present EvidenceNet, a disease-specific dataset of record-level evidence collections and corresponding graph representations derived from full-text biomedical literature. EvidenceNet uses a large language model (LLM)-assisted pipeline to extract experimentally grounded findings as structured evidence records, normalize biomedical entities, score evidence quality, and connect related records through typed semantic relations. We release EvidenceNet-HCC with 7,872 evidence records and a corresponding graph with 10,328 nodes and 49,756 edges, and EvidenceNet-CRC with 6,622 records and a corresponding graph with 8,795 nodes and 39,361 edges. Technical validation shows high component fidelity, including 98.3% field-level extraction accuracy, 100.0% high-confidence entity-link accuracy, 87.5% fusion integrity, and 90.0% semantic relation-type accuracy. Downstream analyses show that the data support retrieval-augmented question answering and graph-based tasks such as future link prediction and target prioritization. These results establish EvidenceNet as a disease-specific biomedical knowledge base dataset for evidence-aware analysis and reuse.

Abstract:Biomedical knowledge resources often either preserve evidence as unstructured text or compress it into flat triples that omit study design, provenance, and quantitative support. Here we present EvidenceNet, a disease-specific dataset of record-level evidence collections and corresponding graph representations derived from full-text biomedical literature. EvidenceNet uses a large language model (LLM)-assisted pipeline to extract experimentally grounded findings as structured evidence records, normalize biomedical entities, score evidence quality, and connect related records through typed semantic relations. We release EvidenceNet-HCC with 7,872 evidence records and a corresponding graph with 10,328 nodes and 49,756 edges, and EvidenceNet-CRC with 6,622 records and a corresponding graph with 8,795 nodes and 39,361 edges. Technical validation shows high component fidelity, including 98.3% field-level extraction accuracy, 100.0% high-confidence entity-link accuracy, 87.5% fusion integrity, and 90.0% semantic relation-type accuracy. Downstream analyses show that the data support retrieval-augmented question answering and graph-based tasks such as future link prediction and target prioritization. These results establish EvidenceNet as a disease-specific biomedical knowledge base dataset for evidence-aware analysis and reuse.

Computational Engineering, Finance, and Science (cs.CE); Artificial Intelligence (cs.AI)

arXiv:2603.28325 [cs.CE]

(or arXiv:2603.28325v4 [cs.CE] for this version)

https://doi.org/10.48550/arXiv.2603.28325 Focus to learn more arXiv-issued DOI via DataCite

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Full text under the publisher's open licence · 265 words

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