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Asterism is a novel AI framework that synthesizes scattered scientific observations into unified theories while preserving researcher intuition, addressing the key limitation of current LLM-driven approaches that often automate away critical human choices. By extracting concept-relation triples from hundreds of papers and organizing them into a hierarchical ontology, the system enables researchers in fields like immunology and agriculture to curate evidence graphs and formulate targeted hypotheses for follow-up experiments. This tool represents a significant advancement in how AI supports complex scientific discovery rather than merely generating content.
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Asterism: Exploring and Synthesizing Scattered Observations into Literature-Grounded Hypotheses and Theories

arXiv2 min read

arXiv:2610.02673v1 Announce Type: cross Abstract: A theory draws many independent observations into one framework with novel hypotheses. A researcher building such a theory must synthesize observations scattered across many papers, each describing related concepts but often in different terms. Which concepts matter most also depends on their preferences and research questions. Recent approaches scale theory synthesis with LLMs, but automate away choices and intuitions from researchers. We present Asterism, which extracts observations from hundreds of papers as concept-relation triples, with concepts unified in a hierarchical ontology. Researchers curate an evidence graph using the ontology and aggregate observations at different levels of granularity to focus theory formation on specific phenomena of interest. In a field deployment (n=10), researchers worked from observations to theories, and kept concepts and hypotheses fitting their preferences. In two case studies, teams of immunology and agriculture researchers discovered mechanisms outside their standard analyses and constructed hypotheses worth follow-up experiments.

Authors:Joseph Chee Chang, Michael D'Arcy, Amy X. Zhang, Pao Siangliulue, Sangho Suh, Aakanksha Naik, Jena D. Hwang, Javier Ramos Benitez, Stella Wroblewski, Matt Latzke, Michael Cuoco, Ruben Lozano-Aguilera, Kris Ganjam, Joel Chan, Doug Downey, Peter Jansen, Kyle J. Travaglini, Daniel S. Weld

Abstract:A theory draws many independent observations into one framework with novel hypotheses. A researcher building such a theory must synthesize observations scattered across many papers, each describing related concepts but often in different terms. Which concepts matter most also depends on their preferences and research questions. Recent approaches scale theory synthesis with LLMs, but automate away choices and intuitions from researchers. We present Asterism, which extracts observations from hundreds of papers as concept-relation triples, with concepts unified in a hierarchical ontology. Researchers curate an evidence graph using the ontology and aggregate observations at different levels of granularity to focus theory formation on specific phenomena of interest. In a field deployment (n=10), researchers worked from observations to theories, and kept concepts and hypotheses fitting their preferences. In two case studies, teams of immunology and agriculture researchers discovered mechanisms outside their standard analyses and constructed hypotheses worth follow-up experiments.

Human-Computer Interaction (cs.HC); Computation and Language (cs.CL); Digital Libraries (cs.DL); Information Retrieval (cs.IR)

arXiv:2610.02673 [cs.HC]

(or arXiv:2610.02673v1 [cs.HC] for this version)

https://doi.org/10.48550/arXiv.2610.02673 arXiv-issued DOI via DataCite (pending registration)

Full text under the publisher's open licence · 217 words

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