aiqbench analysis
This research addresses the critical need for explainability in healthcare AI by proposing a statistically grounded framework that converts continuous medical data into interpretable rules without sacrificing predictive performance. By leveraging Bernoulli Naive Bayes with supervised binarization, the method achieves high AUC scores on benchmark datasets while ensuring model inference can be reproduced using basic arithmetic and reference tables alone. This approach offers a viable path toward trustworthy AI deployment in clinical settings where black-box models are often rejected due to lack of transparency or reproducibility.
A Transportable Threshold-Based Framework for Interpretable Classification of Medical Data
arXiv:2607.15394v1 Announce Type: new Abstract: Black-box models limit the adoption of artificial intelligence in medicine due to their lack of interpretability and reproducibility. We introduce a statistically grounded framework that provides fully interpretable, rule-based clinical classification using the Bernoulli Na\"ive Bayes (BNB) model. The method applies supervised $\chi^2$-guided statistical binarization to continuous variables, identifying thresholds that maximize association with clinical outcomes within the training data. This transformation allows BNB to operate effectively on continuous medical data without sacrificing its inherent transparency. The approach was evaluated on three benchmark datasets, Pima Indians Diabetes, Wisconsin Breast Cancer, and Heart Failure Prediction, achieving area-under-the-curve (AUC) scores of 0.800 for the Pima analysis, 0.984 for Wisconsin Breast Cancer, and 0.919 for Heart Failure Prediction. In addition to discrimination, probabilistic reliability was assessed using leakage-safe cross-validated calibration analysis including Brier score, calibration intercept/slope, and post-hoc beta calibration, which improved probability calibration across datasets. These results suggest that a statistically interpretable framework can achieve performance comparable to more complex models while providing explicit, clinically meaningful decision rules and calibrated risk estimates. To illustrate this transparency concretely, a complete worked example demonstrates that model inference can be reproduced using only a reference table and basic arithmetic, without access to software or proprietary tools. This work offers a practical approach to supporting trustworthy and generalizable AI in real-world healthcare settings.
Abstract:Black-box models limit the adoption of artificial intelligence in medicine due to their lack of interpretability and reproducibility. We introduce a statistically grounded framework that provides fully interpretable, rule-based clinical classification using the Bernoulli Naïve Bayes (BNB) model. The method applies supervised $\chi^2$-guided statistical binarization to continuous variables, identifying thresholds that maximize association with clinical outcomes within the training data. This transformation allows BNB to operate effectively on continuous medical data without sacrificing its inherent transparency. The approach was evaluated on three benchmark datasets, Pima Indians Diabetes, Wisconsin Breast Cancer, and Heart Failure Prediction, achieving area-under-the-curve (AUC) scores of 0.800 for the Pima analysis, 0.984 for Wisconsin Breast Cancer, and 0.919 for Heart Failure Prediction. In addition to discrimination, probabilistic reliability was assessed using leakage-safe cross-validated calibration analysis including Brier score, calibration intercept/slope, and post-hoc beta calibration, which improved probability calibration across datasets. These results suggest that a statistically interpretable framework can achieve performance comparable to more complex models while providing explicit, clinically meaningful decision rules and calibrated risk estimates. To illustrate this transparency concretely, a complete worked example demonstrates that model inference can be reproduced using only a reference table and basic arithmetic, without access to software or proprietary tools. This work offers a practical approach to supporting trustworthy and generalizable AI in real-world healthcare settings.
Machine Learning (cs.LG)
arXiv:2607.15394 [cs.LG]
(or arXiv:2607.15394v1 [cs.LG] for this version)
https://doi.org/10.48550/arXiv.2607.15394 Focus to learn more arXiv-issued DOI via DataCite (pending registration)
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