aiqbench analysis
This research introduces a framework that leverages frozen large language models as shared embedding spaces to predict primary diagnoses from multimodal electronic health record data without fine-tuning. By utilizing linear probes on frozen backbones, the study demonstrates that combining structured and unstructured EHR inputs significantly outperforms traditional baselines while maintaining robustness across datasets. The findings highlight a practical approach for unifying diverse clinical data sources using pre-trained AI representations to enhance diagnostic accuracy in healthcare settings.
A General Multimodal Probing Framework for Data Fusion and Prediction with Frozen Large Language Models: Evidence from Multimodal EHR Data
arXiv:2606.28798v2 Announce Type: replace Abstract: The main objective of this paper is to propose a general framework for prediction based on different sources of multimodal data in the healthcare domain. We evaluated whether frozen medical large language model (LLM) representations can serve as a shared embedding space for multimodal primary diagnosis category prediction. We propose a backbone-flexible probing framework that serializes structured electronic health record (EHR) variables and leakage-pruned discharge-note sections into a shared frozen-LLM representation space and recovers primary diagnosis categories with linear probes, without fine-tuning the LLM. On a MIMIC-IV cohort of 13,645 admissions (seven diagnosis categories), we probed inputs of different modalities (Structured-only, Unstructured-only, and Combined) across transformer layers and six frozen backbones, compared against XGBoost and three text baselines (CAML, LAAT, PLM-ICD) under a matched split and context budget, and tested robustness across datasets on MIMIC-III. The Combined terminal-layer probe reached 88.86% top-1 accuracy on MIMIC-IV, significantly outperforming CAML and PLM-ICD and statistically comparable to LAAT; Combined accuracy ranged from 87.69% to 89.25% across six backbones. On MIMIC-III, in-domain Combined probing reached 74.18% accuracy and significantly exceeded all three baselines, and in a transfer-learning test a 2.8M-parameter adapter on frozen MIMIC-IV representations reached 92.51% accuracy, exceeding adapted LAAT (85.54%). Frozen LLM embeddings unify structured and narrative EHR information: the Combined configuration was strongest in every setting, and its representations transferred across datasets through a compact adapter. Multimodal probing of frozen LLM representations provides a practical, backbone-flexible approach for studying EHR modalities and adapting clinical representations across datasets.
Abstract:The main objective of this paper is to propose a general framework for prediction based on different sources of multimodal data in the healthcare domain. We evaluated whether frozen medical large language model (LLM) representations can serve as a shared embedding space for multimodal primary diagnosis category prediction. We propose a backbone-flexible probing framework that serializes structured electronic health record (EHR) variables and leakage-pruned discharge-note sections into a shared frozen-LLM representation space and recovers primary diagnosis categories with linear probes, without fine-tuning the LLM. On a MIMIC-IV cohort of 13,645 admissions (seven diagnosis categories), we probed inputs of different modalities (Structured-only, Unstructured-only, and Combined) across transformer layers and six frozen backbones, compared against XGBoost and three text baselines (CAML, LAAT, PLM-ICD) under a matched split and context budget, and tested robustness across datasets on MIMIC-III. The Combined terminal-layer probe reached 88.86% top-1 accuracy on MIMIC-IV, significantly outperforming CAML and PLM-ICD and statistically comparable to LAAT; Combined accuracy ranged from 87.69% to 89.25% across six backbones. On MIMIC-III, in-domain Combined probing reached 74.18% accuracy and significantly exceeded all three baselines, and in a transfer-learning test a 2.8M-parameter adapter on frozen MIMIC-IV representations reached 92.51% accuracy, exceeding adapted LAAT (85.54%). Frozen LLM embeddings unify structured and narrative EHR information: the Combined configuration was strongest in every setting, and its representations transferred across datasets through a compact adapter. Multimodal probing of frozen LLM representations provides a practical, backbone-flexible approach for studying EHR modalities and adapting clinical representations across datasets.
Artificial Intelligence (cs.AI); Applications (stat.AP)
arXiv:2606.28798 [cs.AI]
(or arXiv:2606.28798v2 [cs.AI] for this version)
https://doi.org/10.48550/arXiv.2606.28798 Focus to learn more arXiv-issued DOI via DataCite
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website.
Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them.
Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Full text under the publisher's open licence · 340 words
Related coverage
[AINews] not much happened today
Latent Space · Sep 18, 2026
Fusion is not one-size-fits-all: Cross-Modal Representation Alignment for Time-to-Event Modeling
arXiv · Jun 16, 2026
Generalized Multimodal Foundation Model
arXiv · Sep 22, 2026
News
Quantum Computing Report · Jul 25, 2026