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PaCX-MAE introduces a cross-modal distillation framework that injects physiological priors into chest X-ray encoders while maintaining strict unimodal operation at inference. The approach demonstrates significant performance gains on physiology-dependent tasks and exhibits high label efficiency, even in low-data regimes. This work offers a practical pathway for enhancing medical imaging models without requiring complex multi-modal deployment pipelines.
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PaCX-MAE: Physiology-Augmented Chest X-Ray Masked Autoencoder

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arXiv:2606.01537v2 Announce Type: replace-cross Abstract: Clinical diagnosis often requires combining imaging with physiological measurements, yet deployed models typically operate on unimodal data. We present PaCX-MAE, a cross-modal distillation framework that injects physiological priors into chest X-ray (CXR) encoders while remaining strictly unimodal at inference. PaCX-MAE augments in-domain masked autoencoding with a dual contrastive-predictive objective, aligning CXR representations with paired ECG and laboratory embeddings. Extensive evaluation across nine benchmarks demonstrates consistent improvements over domain-specific MAE, particularly on physiology-dependent tasks (e.g., +2.7 AUROC on MedMod; +6.5 F1 on VinDr). The method proves highly label-efficient in the 1% regime and preserves anatomical fidelity, achieving parity with MAE on segmentation tasks. Zero-shot and attention analyses confirm that PaCX-MAE successfully learns to attend to physiological indicators, such as the cardiac silhouette, absent in standard visual pretraining.

Abstract:Clinical diagnosis often requires combining imaging with physiological measurements, yet deployed models typically operate on unimodal data. We present PaCX-MAE, a cross-modal distillation framework that injects physiological priors into chest X-ray (CXR) encoders while remaining strictly unimodal at inference. PaCX-MAE augments in-domain masked autoencoding with a dual contrastive-predictive objective, aligning CXR representations with paired ECG and laboratory embeddings. Extensive evaluation across nine benchmarks demonstrates consistent improvements over domain-specific MAE, particularly on physiology-dependent tasks (e.g., +2.7 AUROC on MedMod; +6.5 F1 on VinDr). The method proves highly label-efficient in the 1% regime and preserves anatomical fidelity, achieving parity with MAE on segmentation tasks. Zero-shot and attention analyses confirm that PaCX-MAE successfully learns to attend to physiological indicators, such as the cardiac silhouette, absent in standard visual pretraining.

Computer Vision and Pattern Recognition (cs.CV); Machine Learning (cs.LG)

arXiv:2606.01537 [cs.CV]

(or arXiv:2606.01537v2 [cs.CV] for this version)

https://doi.org/10.48550/arXiv.2606.01537 Focus to learn more arXiv-issued DOI via DataCite

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