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This paper proposes "Life Operators," a modular framework designed to bridge statistical learning and mechanistic modeling for longitudinal patient prediction in medical AI. By defining distinct roles for perception, evolution, and generation alongside bridge operators, it creates a scalable architecture where neural networks, equations, and physics-based models can be hybridized and locally revised. This approach aims to solve the critical challenge of coupling different biological scales while establishing a verifiable computational foundation for future medical artificial superintelligence.
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Life Operators: a self-evolving framework for multiscale life modelling

arXiv2 min de cititArticolul și perspectiva sunt în engleză.

arXiv:2609.00068v1 Announce Type: cross Abstract: Medical AI is moving beyond recognition towards clinical dialogue and longitudinal prediction. Yet a central question remains: how would a patient's state change under intervention? Statistical models learn future observations, whereas mechanistic models describe selected processes. Neither provides a common framework for representing patient state, coupling scales or revising failed assumptions. We propose Life Operators: task-bounded mappings that define three scientific roles. Perception operators infer task-relevant biological states from multimodal observations, Evolution operators propagate these states under natural or intervention-conditioned dynamics, and Generation operators map them to measurable signals. Each role may be realised by equations, statistical models, neural networks or hybrids. Bridge operators connect components with different variables, scales and time steps. Selected operators and bridges form task-specific Operator Graphs containing the smallest set of states and mechanisms sufficient for a declared claim. This modular structure also makes scientific revision localisable. An AI co-scientist may propose changes to states, operators, bridges or graph structure, while independent evidence determines which variants are retained, restricted or retired. Over time, validated components could accumulate into broader multiscale models of the human body and provide a computational foundation for medical artificial superintelligence.

Abstract:Medical AI is moving beyond recognition towards clinical dialogue and longitudinal prediction. Yet a central question remains: how would a patient's state change under intervention? Statistical models learn future observations, whereas mechanistic models describe selected processes. Neither provides a common framework for representing patient state, coupling scales or revising failed assumptions. We propose Life Operators: task-bounded mappings that define three scientific roles. Perception operators infer task-relevant biological states from multimodal observations, Evolution operators propagate these states under natural or intervention-conditioned dynamics, and Generation operators map them to measurable signals. Each role may be realised by equations, statistical models, neural networks or hybrids. Bridge operators connect components with different variables, scales and time steps. Selected operators and bridges form task-specific Operator Graphs containing the smallest set of states and mechanisms sufficient for a declared claim. This modular structure also makes scientific revision localisable. An AI co-scientist may propose changes to states, operators, bridges or graph structure, while independent evidence determines which variants are retained, restricted or retired. Over time, validated components could accumulate into broader multiscale models of the human body and provide a computational foundation for medical artificial superintelligence.

Computation and Language (cs.CL); Artificial Intelligence (cs.AI); Biological Physics (physics.bio-ph)

arXiv:2609.00068 [cs.CL]

(or arXiv:2609.00068v1 [cs.CL] for this version)

https://doi.org/10.48550/arXiv.2609.00068 Focus to learn more arXiv-issued DOI via DataCite

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