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This paper advances safe reinforcement learning by addressing the continuous-time dynamics inherent in medical treatment, where patient states evolve between discrete clinical interactions. By reformulating the problem as an option-based semi-Markov decision process with trajectory-level safety constraints, it provides finite-sample guarantees that improve both safety and efficacy over standard equidistant scheduling. The work represents a significant methodological step toward deploying robust AI agents in high-stakes healthcare environments where adverse events can occur between observation points.
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Interaction-Limited Safe Continuous-Time RL for Dynamical Medical Treatment

arXiv2 min de cititArticolul și perspectiva sunt în engleză.

arXiv:2606.01051v2 Announce Type: replace Abstract: Dynamic medical treatment requires deciding treatment intensity and intervention timing, while patient states evolve continuously and adverse events may occur between clinical interactions. Most existing treatment learning methods assume fixed schedules or enforce safety only at discrete decision points. We propose Interaction-Limited Safe Continuous-Time Reinforcement Learning, a framework that jointly optimizes treatment administration and clinical interaction timing under trajectory-level safety constraints. Our key idea is to reformulate the continuous time treatment problem as an option-based semi-Markov decision process, where each option specifies a continuous-time treatment policy and its duration. We develop a safety-tightening mechanism showing that suitably constructed constraints at interaction times guarantee safety over the full continuous-time trajectory with high probability. We further establish finite-sample guarantees for policy learning from logged treatment trajectories and introduce a practical data-driven conservative surrogate. Experiments show that the proposed adaptive interaction-timing mechanism improves both safety and treatment effectiveness over equidistant interaction schemes across different safe policy optimization methods.

Abstract:Dynamic medical treatment requires deciding treatment intensity and intervention timing, while patient states evolve continuously and adverse events may occur between clinical interactions. Most existing treatment learning methods assume fixed schedules or enforce safety only at discrete decision points. We propose Interaction-Limited Safe Continuous-Time Reinforcement Learning, a framework that jointly optimizes treatment administration and clinical interaction timing under trajectory-level safety constraints. Our key idea is to reformulate the continuous time treatment problem as an option-based semi-Markov decision process, where each option specifies a continuous-time treatment policy and its duration. We develop a safety-tightening mechanism showing that suitably constructed constraints at interaction times guarantee safety over the full continuous-time trajectory with high probability. We further establish finite-sample guarantees for policy learning from logged treatment trajectories and introduce a practical data-driven conservative surrogate. Experiments show that the proposed adaptive interaction-timing mechanism improves both safety and treatment effectiveness over equidistant interaction schemes across different safe policy optimization methods.

Machine Learning (cs.LG)

arXiv:2606.01051 [cs.LG]

(or arXiv:2606.01051v2 [cs.LG] for this version)

https://doi.org/10.48550/arXiv.2606.01051 Focus to learn more arXiv-issued DOI via DataCite

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