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This research introduces a method for improving sequential screening policies by adapting pretrained models using historical feedback without retraining the base architecture. By anchoring ranking corrections to pre-feedback scores, the approach successfully increases hit recovery rates across multiple base models, including random forests and logistic regression. The technique demonstrates effective transfer learning in constrained experimental budgets where traditional fine-tuning is not feasible.
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Historical-Feature Residual Adaptation for Sequential Screening

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arXiv:2610.19315v1 Announce Type: new Abstract: Sequential screening policies must use acquired feedback effectively under a fixed experiment budget. We study acquisition-time residual adaptation: a small ranking correction built from fixed historical features and anchored to base scores recorded before feedback is revealed. The interface accepts a history-conditioned scorer and a candidate feature table; its primary instantiation augments AssayFormer's ten-dimensional representation with 64 historical directions while retaining the pretrained model. In retrospective evaluation on 20 official-test screens from 15 recorded sources, a comparison fixed before target-outcome access increased source-macro fraction of hits recovered from 22.58% to 28.61%, exceeding all six prespecified comparators. A same-feature ordinary ranking head achieved 25.73%. Supplementary strong logistic, rank-fusion, and unprojected controls achieved 26.42%, 26.02%, and 26.78%, respectively. A separate model-independent pilot on 13 reused development screens reconstructs the features without AssayFormer assets. Across three seeds, residual adaptation improves random-forest hit recovery from 28.87% to 31.27%, while logistic recovery changes from 30.22% to 29.78%. The results show effective pretrained-policy adaptation and useful transfer to an independent nonlinear base, with gains that depend on the base model.

Abstract:Sequential screening policies must use acquired feedback effectively under a fixed experiment budget. We study acquisition-time residual adaptation: a small ranking correction built from fixed historical features and anchored to base scores recorded before feedback is revealed. The interface accepts a history-conditioned scorer and a candidate feature table; its primary instantiation augments AssayFormer's ten-dimensional representation with 64 historical directions while retaining the pretrained model. In retrospective evaluation on 20 official-test screens from 15 recorded sources, a comparison fixed before target-outcome access increased source-macro fraction of hits recovered from 22.58% to 28.61%, exceeding all six prespecified comparators. A same-feature ordinary ranking head achieved 25.73%. Supplementary strong logistic, rank-fusion, and unprojected controls achieved 26.42%, 26.02%, and 26.78%, respectively. A separate model-independent pilot on 13 reused development screens reconstructs the features without AssayFormer assets. Across three seeds, residual adaptation improves random-forest hit recovery from 28.87% to 31.27%, while logistic recovery changes from 30.22% to 29.78%. The results show effective pretrained-policy adaptation and useful transfer to an independent nonlinear base, with gains that depend on the base model.

Machine Learning (cs.LG)

arXiv:2610.19315 [cs.LG]

(or arXiv:2610.19315v1 [cs.LG] for this version)

https://doi.org/10.48550/arXiv.2610.19315 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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