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This arXiv study benchmarks four post-training alignment methods (SFT, DPO, ORPO, GRPO) on small Qwen-2.5 models for generating medication leaflets. Some aligned small models beat GPT-5 on reference-based metrics, but GPT-5 scores better on hallucination and adequacy under LLM-as-judge evaluation, and the authors explicitly say clinical safety and readability still need human verification. For readers, the useful signal is that alignment choice materially affects semantic fidelity and cross-dataset generalization in a high-stakes domain, though the results rest on automated metrics and a single task.
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Exploring Post-Training Alignment of Small Language Models for Biomedical Data-to-Text Generation: A Case Study of Medication Leaflet

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arXiv:2607.13430v2 Announce Type: replace Abstract: Translating structured biomedical information into accurate, patient-friendly narratives remains a challenging biomedical data-to-text (D2T) task. While small language models (SLMs) are attractive for healthcare applications because of their lower computational cost, easier deployment, and improved data governance, the impact of post-training alignment on biomedical D2T generation has not been systematically studied. In this work, we compare four alignment methods: supervised fine-tuning (SFT), direct preference optimization (DPO), odds ratio preference optimization (ORPO), and group relative policy optimization (GRPO), using Qwen-2.5 models for medication leaflet generation. We further introduce FDALeaflets, a dataset derived from OpenFDA drug labels, to evaluate cross-regulatory generalization in a zero-shot setting. Selected aligned SLMs outperform GPT-5 on several reference-based metrics, whereas GPT-5 achieves better hallucination and adequacy scores on FDALeaflets under LLM-as-judge evaluation. Among RL-free alignment methods, ORPO achieves the best in-domain semantic performance, reaching a semantic textual similarity (STS) score of 0.9752. GRPO achieves the highest FDALeaflets STS (0.9407), exceeding GPT-5 (0.9295). These findings show that post-training alignment is a key factor in improving both semantic fidelity and generalization for biomedical D2T generation, while clinical safety and patient readability require human verification.

Abstract:Translating structured biomedical information into accurate, patient-friendly narratives remains a challenging biomedical data-to-text (D2T) task. While small language models (SLMs) are attractive for healthcare applications because of their lower computational cost, easier deployment, and improved data governance, the impact of post-training alignment on biomedical D2T generation has not been systematically studied. In this work, we compare four alignment methods: supervised fine-tuning (SFT), direct preference optimization (DPO), odds ratio preference optimization (ORPO), and group relative policy optimization (GRPO), using Qwen-2.5 models for medication leaflet generation. We further introduce FDALeaflets, a dataset derived from OpenFDA drug labels, to evaluate cross-regulatory generalization in a zero-shot setting. Selected aligned SLMs outperform GPT-5 on several reference-based metrics, whereas GPT-5 achieves better hallucination and adequacy scores on FDALeaflets under LLM-as-judge evaluation. Among RL-free alignment methods, ORPO achieves the best in-domain semantic performance, reaching a semantic textual similarity (STS) score of 0.9752. GRPO achieves the highest FDALeaflets STS (0.9407), exceeding GPT-5 (0.9295). These findings show that post-training alignment is a key factor in improving both semantic fidelity and generalization for biomedical D2T generation, while clinical safety and patient readability require human verification.

Computation and Language (cs.CL)

arXiv:2607.13430 [cs.CL]

(or arXiv:2607.13430v2 [cs.CL] for this version)

https://doi.org/10.48550/arXiv.2607.13430 Focus to learn more arXiv-issued DOI via DataCite

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