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This research demonstrates a generative AI model capable of predicting radiotherapy dose distributions based on user-defined preferences rather than biased reference plans, offering greater personalization in clinical settings. By prioritizing specific trade-offs between organs-at-risk and target volumes, the approach aims to improve adaptability and plan quality over existing industry standards like Varian RapidPlan. The study highlights a significant advancement in applying machine learning to solve complex, institution-specific problems in medical physics.
Demo: Generative AI helps Radiotherapy Planning with User Preference
arXiv:2512.08996v2 Announce Type: replace-cross Abstract: Radiotherapy planning is a highly complex process that often varies significantly across institutions and individual planners. Most existing deep learning approaches for 3D dose prediction rely on reference plans as ground truth during training, which can inadvertently bias models toward specific planning styles or institutional preferences. In this study, we introduce a novel generative model that predicts 3D dose distributions based solely on user-defined preference flavors. These customizable preferences enable planners to prioritize specific trade-offs between organs-at-risk (OARs) and planning target volumes (PTVs), offering greater flexibility and personalization. Designed for seamless integration with clinical treatment planning systems, our approach assists users in generating high-quality plans efficiently. Comparative evaluations demonstrate that our method can surpasses the Varian RapidPlan model in both adaptability and plan quality in some scenarios.
Abstract:Radiotherapy planning is a highly complex process that often varies significantly across institutions and individual planners. Most existing deep learning approaches for 3D dose prediction rely on reference plans as ground truth during training, which can inadvertently bias models toward specific planning styles or institutional preferences. In this study, we introduce a novel generative model that predicts 3D dose distributions based solely on user-defined preference flavors. These customizable preferences enable planners to prioritize specific trade-offs between organs-at-risk (OARs) and planning target volumes (PTVs), offering greater flexibility and personalization. Designed for seamless integration with clinical treatment planning systems, our approach assists users in generating high-quality plans efficiently. Comparative evaluations demonstrate that our method can surpasses the Varian RapidPlan model in both adaptability and plan quality in some scenarios.
Computer Vision and Pattern Recognition (cs.CV); Artificial Intelligence (cs.AI); Machine Learning (cs.LG)
arXiv:2512.08996 [cs.CV]
(or arXiv:2512.08996v2 [cs.CV] for this version)
https://doi.org/10.48550/arXiv.2512.08996 Focus to learn more arXiv-issued DOI via DataCite
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