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CG-GLORE advances medical imaging by integrating second-order optimization principles into deep learning for sparse-view CT reconstruction, directly addressing the ill-posed nature of low-dose scans. The architecture balances computational efficiency with high-fidelity image recovery through a hybrid global-local regularization network that captures both local textures and long-range anatomical dependencies. This work represents significant progress in applying advanced machine learning techniques to solve complex inverse problems in healthcare physics.
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CG-GLORE: A Conjugate Gradient-Based Global-Local Regularization Network for Sparse-View CT Reconstruction

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arXiv:2608.15246v1 Announce Type: cross Abstract: Sparse-view computed tomography (CT) reduces radiation dose by acquiring fewer projection views, but the resulting inverse problem is highly ill-posed and often produces severe streak artifacts. Existing deep reconstruction methods have achieved promising performance, yet many rely on first-order updates or large regularization networks, which can be less effective in ill-conditioned settings. We propose \textbf{CG-GLORE}, a compact deep unrolling framework inspired by second-order optimization for sparse-view CT reconstruction. Each unrolled stage uses a CG-solved linear system based on a structured Hessian surrogate: it retains the physics-induced curvature of the data-fidelity term while using an identity approximation for the learned regularization term. Thus, the method is second-order-inspired rather than an exact Newton method for the full learned objective. To model image priors, we design a Global-Local Regularization Network (GLORE), which combines convolutional local feature extraction with a Long-Range Dependency Representation module based on sparse patchification and Nystr\"{o}m attention. This design captures anatomical details and non-local dependencies while maintaining practical complexity. Experiments on AAPM and DeepLesion under multiple sparse-view and noise settings show that CG-GLORE achieves strong quantitative performance, stable convergence, lower noise power, and improved visual fidelity compared with representative reconstruction methods.

Abstract:Sparse-view computed tomography (CT) reduces radiation dose by acquiring fewer projection views, but the resulting inverse problem is highly ill-posed and often produces severe streak artifacts. Existing deep reconstruction methods have achieved promising performance, yet many rely on first-order updates or large regularization networks, which can be less effective in ill-conditioned settings. We propose \textbf{CG-GLORE}, a compact deep unrolling framework inspired by second-order optimization for sparse-view CT reconstruction. Each unrolled stage uses a CG-solved linear system based on a structured Hessian surrogate: it retains the physics-induced curvature of the data-fidelity term while using an identity approximation for the learned regularization term. Thus, the method is second-order-inspired rather than an exact Newton method for the full learned objective. To model image priors, we design a Global-Local Regularization Network (GLORE), which combines convolutional local feature extraction with a Long-Range Dependency Representation module based on sparse patchification and Nyström attention. This design captures anatomical details and non-local dependencies while maintaining practical complexity. Experiments on AAPM and DeepLesion under multiple sparse-view and noise settings show that CG-GLORE achieves strong quantitative performance, stable convergence, lower noise power, and improved visual fidelity compared with representative reconstruction methods.

Computer Vision and Pattern Recognition (cs.CV); Artificial Intelligence (cs.AI)

arXiv:2608.15246 [cs.CV]

(or arXiv:2608.15246v1 [cs.CV] for this version)

https://doi.org/10.48550/arXiv.2608.15246 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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