BioEVAL: A global, multi-institutional benchmark of large language and multimodal models for bioengineering

arXiv:2609.30489v1 Announce Type: new Abstract: Large Language Models (LLMs) have demonstrated historic breakthroughs in general reasoning with early successes in biomedical science. However, existing LLM benchmarking emphasizes factual recall, offering limited insight into model performance on frontier and multimodal tasks. We assembled BioEVAL (BioEngineering Validation of AI and LLMs), a global, multi-institutional initiative designed to assess experimental reasoning capability across bioengineering (BE) subfields. BioEVAL spans 11 major BE subfields plus a set of uncategorized items, bringing together 22 research groups to create a PhD-level benchmark comprising 608 evaluation items: 1) 380 multiple-choice questions (MCQs, 359 retained after audit), 2) 218 literature synthesis tasks, and 3) 10 multimodal problems with experimental image interpretation. Benchmark items underwent authoring-group expert review and centralized quality control before evaluation. Following evaluation, a blinded cross-group consensus audit of the highest- and lowest-accuracy MCQ items flagged 21 questions for revision or removal; these were withheld, and all reported MCQ results are computed on the 359 retained items. We evaluated diverse cloud-scale foundation/multimodal models (e.g., ChatGPT, Gemini, and Grok) and locally deployable models suitable for inference on consumer-grade GPUs. Models achieved the highest accuracy of up to 90% on MCQs, similarity score of 0.72 on literature synthesis, and accuracy of 80% on a small sample of multimodal reasoning questions, with substantial performance variation across subfields. Leaderboard rankings characterize current capabilities, limitations, and development priorities across the evaluated BE task categories. BioEVAL is maintained as an extensible benchmark with standardized protocols for continuing expert item contribution and model evaluation.

Authors:Shun Ye, Vinny Chandran Suja, Chenlong Li, Chongming Jiang, Reza Zamani, Xiang Li, Christopher Bain, Yuqi Zhou, Walker Peterson, Huidong Wang, Chenglang Hu, Jongchan Park, Xiao Cheng, Benjamin Swedlund, Sandra Murillo, Anjali Sivanandan, Shiyu Sun, Liang Lanfeng, Mohammad Tariqul Islam, Baju C. Joy, Ishaq N. Khan, Sreedhar S. Kumar, Gabriel Mercado-Vásquez, James V. Vizzard, Jonathan M. Matthews, Helen Huang, Xiaolu Guo, Ethan Nicklow, Guorui Chen, Ryan A. Neff, Surjendu Maity, Hyeonjin Park, Han-ho Joo, Katherine Dong, Yuyan Cai, Weihang Huang, Yichen Zou, Rui Yan, Raphael Figueroa, Artem Goncharov, Bella Rose Schremmer, Lian Elsa Linton, Keisuke Goda, Liang Gao, Ke Cheng, Leonardo Morsut, Jennifer L. Wilson, Jianping Fu, Lim Chwee Teck, Deblina Sarkar, Andreas Hierlemann, Savaş Tay, Alexander Hoffmann, Donald Richieri Griffin, Jun Chen, Shana O. Kelley, Shyni Varghese, Jinwoo Cheon, Wilbur A. Lam, James J. Moon, Wilson W. Wong, Samir Mitragotri, Dino Di Carlo

Abstract:Large Language Models (LLMs) have demonstrated historic breakthroughs in general reasoning with early successes in biomedical science. However, existing LLM benchmarking emphasizes factual recall, offering limited insight into model performance on frontier and multimodal tasks. We assembled BioEVAL (BioEngineering Validation of AI and LLMs), a global, multi-institutional initiative designed to assess experimental reasoning capability across bioengineering (BE) subfields. BioEVAL spans 11 major BE subfields plus a set of uncategorized items, bringing together 22 research groups to create a PhD-level benchmark comprising 608 evaluation items: 1) 380 multiple-choice questions (MCQs, 359 retained after audit), 2) 218 literature synthesis tasks, and 3) 10 multimodal problems with experimental image interpretation. Benchmark items underwent authoring-group expert review and centralized quality control before evaluation. Following evaluation, a blinded cross-group consensus audit of the highest- and lowest-accuracy MCQ items flagged 21 questions for revision or removal; these were withheld, and all reported MCQ results are computed on the 359 retained items. We evaluated diverse cloud-scale foundation/multimodal models (e.g., ChatGPT, Gemini, and Grok) and locally deployable models suitable for inference on consumer-grade GPUs. Models achieved the highest accuracy of up to 90% on MCQs, similarity score of 0.72 on literature synthesis, and accuracy of 80% on a small sample of multimodal reasoning questions, with substantial performance variation across subfields. Leaderboard rankings characterize current capabilities, limitations, and development priorities across the evaluated BE task categories. BioEVAL is maintained as an extensible benchmark with standardized protocols for continuing expert item contribution and model evaluation.

Artificial Intelligence (cs.AI)

arXiv:2609.30489 [cs.AI]

(or arXiv:2609.30489v1 [cs.AI] for this version)

https://doi.org/10.48550/arXiv.2609.30489 arXiv-issued DOI via DataCite (pending registration)

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BioEVAL: A global, multi-institutional benchmark of large language and multimodal models for bioengineering

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