A Guideline-Augmented Multi-Agent Framework for Schema-as-Code Biomedical Named Entity Recognition

Abstract:Large language models (LLMs) have shown promising potential for biomedical named entity recognition (BioNER) through instruction following and in-context learning. However, existing LLM-based BioNER methods still face two key limitations. First, retrieved demonstrations and external biomedical knowledge provide limited support for dataset-specific annotation semantics, leaving entity boundaries, type scopes, and annotation conventions ambiguous. Second, free-form generation lacks sufficient structural control, often leading to invalid formats, hallucinated mentions, duplicated entities, and boundary errors. To address these limitations, we propose GAMA, a guideline-augmented multi-agent framework for schema-as-code BioNER. GAMA first induces candidate annotation rules from labeled training instances and verifies them against annotated data to construct reliable dataset-specific guideline memory. Guided by these verified rules, a planning component generates ranked span-type hypotheses with rationales, and a coding component converts them into schema-constrained entity objects. A verification module then checks span grounding, type validity, and structural compliance, and performs dual-loop refinement to correct invalid or low-confidence predictions. Experiments on five widely used BioNER datasets with multiple LLM backbones show that GAMA consistently outperforms strong LLM-based baselines. Ablation and parameter analyses further verify the effectiveness of the proposed components.

Computation and Language (cs.CL)

arXiv:2610.02970 [cs.CL]

(or arXiv:2610.02970v1 [cs.CL] for this version)

https://doi.org/10.48550/arXiv.2610.02970 Focus to learn more arXiv-issued DOI via DataCite (pending registration)

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